Processing and activation of recombinant mouse mastocytoma histidine decarboxylase in the particulate fraction of Sf9 cells by porcine pancreatic elastase.
نویسندگان
چکیده
Mature 53 kDa histidine decarboxylase (HDC) peptide is produced from a precursor 74 kDa peptide. The mechanism of specific cleavage by processing enzyme is unknown. Using the recombinant mouse 74 kDa HDC, we found that porcine pancreatic elastase specifically converted the inactive 74 kDa HDC to its active form of 53 kDa HDC.
منابع مشابه
Deletion of histidine decarboxylase (HDC) enhances the antinociceptive effects of orexin A in the central nervous system
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ورودعنوان ژورنال:
- Biochimica et biophysica acta
دوره 1253 1 شماره
صفحات -
تاریخ انتشار 1995